Mthfr

Psyche · 07-06-2016, 07:05 PM

Can anyone tell me about it? I just downloaded my DNA into promethease. I carry one of the mutations. The note says "60% efficiency in processing folic acid could have somewhat elevated homocysteine and low b12/folate"

What am I supposed to do with this information?

I'm not surprised either. But I don't know what to do with the information

Chaos Coordinator · 07-06-2016, 09:31 PM

If you have symptoms like tiredness, anxiety, mood or sleep issues....you can take methylated folate

What symptoms do you have? My next step would depend on that.

Psyche · 07-07-2016, 04:45 AM

Um yeah. Lol. I recently started anti anxiety meds. Depression has been a reoccurring issue and I have a standing script for lunesta (after trying all sorts of herbal supplements)

Chaos Coordinator · 07-07-2016, 06:47 AM

oh, yes. methylated folate.

start there.

charla · 07-07-2016, 08:46 AM

I just recently found out I have this mutation along with COMT. I have started methylation complete supplement that includes methyl b-12, Folate and 5-Mthf. I'm sleeping better and my anxiety has lessened some. I will start SAM-E next month but I can't remember if that is for MTHFR or COMT mutation. Another thing that I will be addressing soon with my doctor is the leaky gut that these mutations can cause because I have resulting autoimmune diseases.

Psyche · 07-07-2016, 01:15 PM

So is there a methyl folate that has other b vitamins in them like b12? And niacin, etc? Should I stop taking my b complex with folic acid?

sweetpeasmommy · 07-07-2016, 02:43 PM

If you have expressed COMT mutations which many people with anxiety do, you might be sensitive to methyl donors. You can run your data through nutra hacker or genetic genie for free to see if that might be an issue or look it up on Promethease which is a fun tool but not the most helpful as far as supplementation is concerned. Besides not being able to use methylfolate in cases where COMT is expressed, it also causes some issues with being able to use certain forms of B vitamins. If I gave C methylfolate, methyl B12, or the regular form of B6 he would be super irritable, anxious and climbing the walls. BTDT.

In cases if MTHFR where methyl donors are not tolerated, calcium folinate can be used instead. For C, his genetic practitioner did not feel that his MTHFR was expressed at this time and felt that other mutations were more of a priority to address. He is hetero on the AC1298 allele though, if your report says 60% reduction then you are probably hetero on the C677T allele and that is more significant and probably requires treatment.

Katigre · 07-07-2016, 03:18 PM

Ask your dr about starting Deplin which is especially for people with mtfr. It's helped my dh's meds work better.

---------- Post added at 05:18 PM ---------- Previous post was at 05:17 PM ----------

https://www.deplin.com

Psyche · 07-07-2016, 03:46 PM

I see a general practitioner who isn't even soggy on the crunchy scale. Will a general practitioner be up on this?

And thank your for the advice so far! I did promethease and I'll look into the other ones.

sweetpeasmommy · 07-07-2016, 05:28 PM

Yes, IME they will be sort of up on it. They might consider a hetero mutation to not be a big deal especially if you aren't planning on having any more pregnancies but ymmv.

Sent from my iPad using Tapatalk

twentysixcats · 07-07-2016, 06:50 PM

The best article written in layman's terms that I've read to explain how the MTHFR can affect someone is this: http://www.easytolovebut.com/?p=2782

I'm homozygous for the mutation. My PCP hadn't even heard of MTHFR, though my psych had and was familiar with research about it. I'm on Zoloft for depression and my psych said evidence shows that people with MTHFR do better with methylated folate supplements in addition to SSRIs.

I take Thorne's Methyl-Guard Plus (as recommended by my midwife). It has folate as well as B2, B6, and B12.

Psyche · 07-07-2016, 06:59 PM

Okay. So my report says to avoid methyl b12 for some genetic markers then goes on to tell me in others that I need methyl b 12.

Interestingly it also tells me to avoid cumin and grapefruit (I don't like either) and that I'm sensitive to green tea which I also don't enjoy.

So I'm basically still lost. Try b6 and methyl b12?

sweetpeasmommy · 07-07-2016, 07:09 PM

You need b12 but probably a different form than methyl. http://www.globalhealingcenter.com/n...s-vitamin-b12/

Sent from my iPhone using Tapatalk

JellyBean · 07-17-2016, 08:39 AM

Plexus's vitamin xfactor recently changed their ingredients because a lot of the ambassadors have this gene mutation! It does have methylated folate, methylcobalamin b-12 and niacin. I don't want to sound like I came to this board to push plexus though so don't buy it from me!! If you are interested i can tell you how all the gcm'ers are who sell and/or send you the label so you can see what else is in it!!! It's a decent price point and has a money back guarantee if you end up not loving it.

Chaos Coordinator · 07-25-2016, 12:06 PM

I was wondering because my sister tried to get me on board with plexus and I was turned off by it having folic acid instead of methylated folate. Now I might have to talk to her again.

07-06-2016, 07:05 PM	#1
Psyche Rose Garden Srsly? Join Date: Jul 2007 Location: DFW Posts: 24,442	Mthfr Can anyone tell me about it? I just downloaded my DNA into promethease. I carry one of the mutations. The note says "60% efficiency in processing folic acid could have somewhat elevated homocysteine and low b12/folate" What am I supposed to do with this information? I'm not surprised either. But I don't know what to do with the information __________________ Heather (ISTJ) working full time, wife to Jason since '02, mom to C 12 years old, J 9 years old , and T 6 years old , mouse catching, Izzy, and rabbit chasing, Ellie.

07-06-2016, 09:31 PM	#2
Chaos Coordinator Rose Garden They need freedom to just be fluffy mashed potatoes and feel their fluffy feelings. Join Date: Oct 2009 Location: Up to my earballs in little boys. Posts: 20,259	Re: Mthfr If you have symptoms like tiredness, anxiety, mood or sleep issues....you can take methylated folate What symptoms do you have? My next step would depend on that. __________________ Joy Progressive Methodist Enfp mama to Sparrow, 10 Zion, 7.5 Baby Gus, 4.5 Preschool teacher. Musician. Timelord. Www.justicemercymayhem.wordpress.com "What you plant in the kingdom will surely grow, and what you grow with love will surely bloom, and the fruit of the spirit will come back to you."

07-07-2016, 04:45 AM	#3
Psyche Rose Garden Srsly? Join Date: Jul 2007 Location: DFW Posts: 24,442	Re: Mthfr Um yeah. Lol. I recently started anti anxiety meds. Depression has been a reoccurring issue and I have a standing script for lunesta (after trying all sorts of herbal supplements) __________________ Heather (ISTJ) working full time, wife to Jason since '02, mom to C 12 years old, J 9 years old , and T 6 years old , mouse catching, Izzy, and rabbit chasing, Ellie.

07-07-2016, 06:47 AM	#4
Chaos Coordinator Rose Garden They need freedom to just be fluffy mashed potatoes and feel their fluffy feelings. Join Date: Oct 2009 Location: Up to my earballs in little boys. Posts: 20,259	Re: Mthfr oh, yes. methylated folate. start there. __________________ Joy Progressive Methodist Enfp mama to Sparrow, 10 Zion, 7.5 Baby Gus, 4.5 Preschool teacher. Musician. Timelord. Www.justicemercymayhem.wordpress.com "What you plant in the kingdom will surely grow, and what you grow with love will surely bloom, and the fruit of the spirit will come back to you."

07-07-2016, 08:46 AM	#5
charla Administrator Join Date: Jan 2008 Location: Oklahoma Posts: 16,663	Re: Mthfr I just recently found out I have this mutation along with COMT. I have started methylation complete supplement that includes methyl b-12, Folate and 5-Mthf. I'm sleeping better and my anxiety has lessened some. I will start SAM-E next month but I can't remember if that is for MTHFR or COMT mutation. Another thing that I will be addressing soon with my doctor is the leaky gut that these mutations can cause because I have resulting autoimmune diseases. __________________ CHARLA Married to Nick, 31 yrs Mom to Nathan and his wife Abby, and Hope Elizabeth, dancing for eternity with babies: Micah Noel, Grace Anna, Andrew David www.dancingforeternity.org www.irresistiblehope.org Save Save Save Save Save

07-07-2016, 01:15 PM	#6
Psyche Rose Garden Srsly? Join Date: Jul 2007 Location: DFW Posts: 24,442	Re: Mthfr So is there a methyl folate that has other b vitamins in them like b12? And niacin, etc? Should I stop taking my b complex with folic acid? __________________ Heather (ISTJ) working full time, wife to Jason since '02, mom to C 12 years old, J 9 years old , and T 6 years old , mouse catching, Izzy, and rabbit chasing, Ellie.

07-07-2016, 02:43 PM	#7
sweetpeasmommy Rose Garden Join Date: Aug 2008 Posts: 30,329	Re: Mthfr If you have expressed COMT mutations which many people with anxiety do, you might be sensitive to methyl donors. You can run your data through nutra hacker or genetic genie for free to see if that might be an issue or look it up on Promethease which is a fun tool but not the most helpful as far as supplementation is concerned. Besides not being able to use methylfolate in cases where COMT is expressed, it also causes some issues with being able to use certain forms of B vitamins. If I gave C methylfolate, methyl B12, or the regular form of B6 he would be super irritable, anxious and climbing the walls. BTDT. In cases if MTHFR where methyl donors are not tolerated, calcium folinate can be used instead. For C, his genetic practitioner did not feel that his MTHFR was expressed at this time and felt that other mutations were more of a priority to address. He is hetero on the AC1298 allele though, if your report says 60% reduction then you are probably hetero on the C677T allele and that is more significant and probably requires treatment. __________________ Amy eNFp Wife to ISTJ DH 1997 Mom to one Sweet Boy 10/2004

07-07-2016, 03:18 PM	#8
Katigre Rose Garden Why thank you, it is naturally blue... Join Date: Mar 2005 Posts: 21,278	Re: Mthfr Ask your dr about starting Deplin which is especially for people with mtfr. It's helped my dh's meds work better. ---------- Post added at 05:18 PM ---------- Previous post was at 05:17 PM ---------- https://www.deplin.com

07-07-2016, 03:46 PM	#9
Psyche Rose Garden Srsly? Join Date: Jul 2007 Location: DFW Posts: 24,442	Re: Mthfr I see a general practitioner who isn't even soggy on the crunchy scale. Will a general practitioner be up on this? And thank your for the advice so far! I did promethease and I'll look into the other ones. __________________ Heather (ISTJ) working full time, wife to Jason since '02, mom to C 12 years old, J 9 years old , and T 6 years old , mouse catching, Izzy, and rabbit chasing, Ellie.

07-07-2016, 05:28 PM	#10
sweetpeasmommy Rose Garden Join Date: Aug 2008 Posts: 30,329	Re: Mthfr Yes, IME they will be sort of up on it. They might consider a hetero mutation to not be a big deal especially if you aren't planning on having any more pregnancies but ymmv. Sent from my iPad using Tapatalk __________________ Amy eNFp Wife to ISTJ DH 1997 Mom to one Sweet Boy 10/2004

07-07-2016, 06:50 PM	#11
twentysixcats Rose Garden Join Date: Jan 2011 Location: Atlanta, GA Posts: 6,404	Re: Mthfr The best article written in layman's terms that I've read to explain how the MTHFR can affect someone is this: http://www.easytolovebut.com/?p=2782 I'm homozygous for the mutation. My PCP hadn't even heard of MTHFR, though my psych had and was familiar with research about it. I'm on Zoloft for depression and my psych said evidence shows that people with MTHFR do better with methylated folate supplements in addition to SSRIs. I take Thorne's Methyl-Guard Plus (as recommended by my midwife). It has folate as well as B2, B6, and B12. __________________ Ashley (ISFJ) mom to three beautiful girls! DD1 (8/2009) DD2 (7/2012) DD3 (9/2014)

07-07-2016, 06:59 PM	#12
Psyche Rose Garden Srsly? Join Date: Jul 2007 Location: DFW Posts: 24,442	Re: Mthfr Okay. So my report says to avoid methyl b12 for some genetic markers then goes on to tell me in others that I need methyl b 12. Interestingly it also tells me to avoid cumin and grapefruit (I don't like either) and that I'm sensitive to green tea which I also don't enjoy. So I'm basically still lost. Try b6 and methyl b12? __________________ Heather (ISTJ) working full time, wife to Jason since '02, mom to C 12 years old, J 9 years old , and T 6 years old , mouse catching, Izzy, and rabbit chasing, Ellie.

07-07-2016, 07:09 PM	#13
sweetpeasmommy Rose Garden Join Date: Aug 2008 Posts: 30,329	Re: Mthfr You need b12 but probably a different form than methyl. http://www.globalhealingcenter.com/n...s-vitamin-b12/ Sent from my iPhone using Tapatalk __________________ Amy eNFp Wife to ISTJ DH 1997 Mom to one Sweet Boy 10/2004

07-17-2016, 08:39 AM	#14
JellyBean Rose Garden Join Date: Mar 2006 Location: The Woods Posts: 5,590	Re: Mthfr Plexus's vitamin xfactor recently changed their ingredients because a lot of the ambassadors have this gene mutation! It does have methylated folate, methylcobalamin b-12 and niacin. I don't want to sound like I came to this board to push plexus though so don't buy it from me!! If you are interested i can tell you how all the gcm'ers are who sell and/or send you the label so you can see what else is in it!!! It's a decent price point and has a money back guarantee if you end up not loving it. __________________ Wife to Fair Trade Chocolate Kiss 12/2000 Mommy to PopRocks 3/2005, two sweet starbursts 3/2009 and my little milkdud 7/11

07-25-2016, 12:06 PM	#15
Chaos Coordinator Rose Garden They need freedom to just be fluffy mashed potatoes and feel their fluffy feelings. Join Date: Oct 2009 Location: Up to my earballs in little boys. Posts: 20,259	Re: Mthfr I was wondering because my sister tried to get me on board with plexus and I was turned off by it having folic acid instead of methylated folate. Now I might have to talk to her again. __________________ Joy Progressive Methodist Enfp mama to Sparrow, 10 Zion, 7.5 Baby Gus, 4.5 Preschool teacher. Musician. Timelord. Www.justicemercymayhem.wordpress.com "What you plant in the kingdom will surely grow, and what you grow with love will surely bloom, and the fruit of the spirit will come back to you."

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